MAPK -| TSC
mTOR/rictor -> AKT
EGFR -> Ras
PI-3-K -> AKT
AMPK -> TSC
AKT -| AMPK
mTOR/rictor -> pS6K
AKT -| C-Raf
pS6K -> pS6
Ras -> C-Raf
C-Raf -> MEK
GSK3b -> TSC
MAPK -| EGFR
Rheb -> mTOR/rictor
MEK -> MAPK
TSC -| Rheb
RSK -| TSC
MAPK -> RSK
pS6K -| EGFR
mTOR/rictor -> 4-EBP
AKT -| GSK3b
AKT -| TSC
LKB -> AMPK
EGFR -> PI-3-K
MAPK -> pS6K
BEGIN LAYOUT
NODE PI-3-K 117.0 102.0
NODE AMPK 201.0 250.0
NODE Ras 374.0 105.0
NODE GSK3b 324.0 209.0
NODE AKT 80.0 159.0
NODE 4-EBP 177.0 374.0
NODE TSC 251.0 283.0
NODE Rheb 251.0 324.0
NODE MEK 378.0 199.0
NODE RSK 375.0 288.0
NODE C-Raf 377.0 157.0
NODE pS6K 69.0 394.0
NODE EGFR 249.0 17.0
NODE MAPK 375.0 247.0
NODE pS6 177.0 442.0
NODE LKB 202.0 203.0
NODE mTOR/rictor 80.0 316.0
EDGE MAPK EGFR 424.0 221.0 420.0 43.0
EDGE pS6K EGFR 27.0 385.0 34.0 62.0
EDGE AKT GSK3b 156.0 179.0 276.0 180.0
EDGE AKT TSC 96.0 204.0 96.0 284.0
EDGE MAPK pS6K 425.0 264.0 424.0 395.0